Validated Spectrophotometric Methods for the Determination of Amiodarone Hydrochloride in Commercial Dosage Forms Using p-Chloranilic Acid and 2,3-Dichloro-5,6-dicyano-1,4-benzoquinone

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Validated spectrophotometric methods for the determination of amiodarone hydrochloride in commercial dosage forms using p-chloranilic acid and 2,3-dichloro-5,6-dicyano-1,4-benzoquinone.

Two simple, sensitive and economical spectrophotometric methods have been developed for the determination of amiodarone hydrochloride in pure form and commercial dosage form. These methods (A and B) are based on the reaction of amiodarone base as n-electron donor with p-chloranilic acid and 2,3-dichloro-5,6-dicyano-1,4-benzoquinone (DDQ) as pi-acceptors to give highly colored complex species wh...

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Six drugs viz., Astemizole, Domperidone, Esomeprazole, Losartan potassium, Sumatriptan and Terazosin were tested for the formation of charge transfer complexes with 2, 3-dichloro 5, 6-dicyanopbenzoquinone, (DDQ). Each of these drugs turned the pale yellow colour of reagent i.e DDQ. in CH3CN, to purple and exhibited three bands at 455, 545 and 588 nm due to anion of the reagent whose intensity i...

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ژورنال

عنوان ژورنال: Analytical Sciences

سال: 2004

ISSN: 0910-6340,1348-2246

DOI: 10.2116/analsci.20.1231